Nasal Steroids, Nasal Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Sinusitis Study (NOSES)

Clinicians & Researchers

We are recruiting participants from the six universities listed below and from their surrounding areas.

We welcome new clinics in and

around these universities!

Georgetown University

(Washington, DC metro area)

Penn State College of Medicine

(Hershey, PA)

University of California – Los Angeles

(Los Angeles, CA)

University of Washington

(Seattle, WA)

University of Wisconsin - Madison

(Madison, WI)

Virginia Commonwealth University

(Richmond, VA)

If interested, contact Dr. Daniel Merenstein, Principal Investigator,

at djm23@georgetown.edu

Study Goal

The study's goal is to improve outcomes for patients with acute rhinosinusitis (ARS) by investigating differing treatments for ARS. Treatments in this investigation include antibiotics, intranasal corticosteroids (INCS), saline nasal irrigation (SNI), and over-the-counter treatments. The data from this study can be used by clinicians and patients to inform effective treatment plans for ARS. We aim to:

Compare patient outcomes between patients randomized to amoxicillin-clavulanate against INCS among patients who do not improve with supportive care.

Identify which patient subgroups benefit the most from oral antibiotics against INCS based on baseline patient and disease characteristics.

Identify which patient subgroups improve with supportive care alone, and do not require additional interventions.

Funding

This study is funded by the Patient-Centered Outcomes Research Institute (PCORI). If you are interested in learning more about PCORI or speaking with the researchers, please contact Daniel Merenstein, MD at djm23@georgetown.edu.

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